科研队伍
肖锐

 

 最后学位:哲学博士(PhD,武汉大学)

 职称职务:教授、博导

 专业方向:功能基因组学;RNA组学

 研究方向:RNA结合蛋白功能基因组学

 电话号码:027-68750197

 电子邮件:xiaorui9@whu.edu.cn

 

教育经历

1999-2003  武汉大学生命科学学院,学士

2004-2010  武汉大学生命科学学院,博士;导师:付向东教授

 

工作经历与任职

2011-2017 美国加州大学圣地亚哥分校医学院细胞与分子医学系,博士后;导师:付向东教授

2017至今  美高梅正规平台网址-网投【鼠年大吉】,教授/博导

2020至今  武汉大学免疫与代谢前沿科学中心,PI

 

研究领域

  RNA结合蛋白在基因转录后的剪接加工、修饰、转运、细胞定位、稳定性、翻译和降解等生物学过程中发挥经典的RNA调控功能;然而,我们近期的一系列研究发现RNA结合蛋白还是一类新型转录因子,它们通过RNA依赖的染色质相互作用直接参与转录调控,开辟了RNA结合蛋白功能研究的新领域[Xiao et al. 2019 Cell;Van Nostrand et al. 2020 Nature; Ji et al. 2013 Cell; Wei et al. 2016 Mol Cell]。本实验室主要采用多组学技术(ChIP-seq、GRO-seq、CLIP-seq、RNA-seq、Hi-C和GRID-seq等),系统地研究RNA结合蛋白的RNA调控、转录与染色质调控功能和相关疾病的发生机制。


获奖、荣誉、学术兼职

Advanced Science等杂志应邀审稿人


目前研究资助

国家自然科学基金面上项目、国家重点研发计划重点专项等。

 

代表性论文

1. Ren, F., Miao, R., Xiao, R.*, Mei, J.* (2020) m6A reader Igf2bp3 enables germ plasm assembly by m6A-dependent regulation of gene expression in zebrafish. Science Bulletin (in press)

2. Du, X., Xiao, R.* (2020) An emerging role of chromatin-interacting RNA-binding proteins in transcription regulation. Essays in Biochemistry https://doi.org/10.1042/EBC20200004

3. Van Nostrand, E.#, Freese, P.#, Pratt, G.#, Wang, X.#, Wei, X.#, Xiao, R.#, Blue, S., Chen, J., Cody, N., Dominguez, D., Olson, S., Sundararaman, B, Zhan, L., Bazile, C., Bouvrette, L., Bergalet, J., Duff, M., Garcia, K., Gelboin-Burkhart, C., Hochman, M., Lambert, N., Li, H., Nguyen, T., Palden, T., Rabano, I., Sathe, S., Stanton, R., Su, A., Wang, R., Yee, B., Zhou, B., Louie, A., Aigner, S., Fu, XD*, Lécuyer, E.*, Burge, C.*, Graveley, B.*, Yeo, G.* (2020) A Large-Scale Binding and Functional Map of Human RNA Binding Proteins. Nature 583: 711-719.

4. The ENCODE Project Consortium et al. (2020) Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature 583, 699–710.

5. The ENCODE Project Consortium et al. (2020) Perspectives on ENCODE. Nature 583, 693–698.

6. Li, Y., Xia, L., Tan, K., Ye, X., Zou, Z., Li, M., Xiao, R., Wang, Z., Liu, X., Deng, M., Cui, J., Yang, M., Luo, Q., Liu, S., Cao, X., Zhu, H., Liu, T., Hu, J., Shi, J., Xiao, S.*, Xia, L.*(2020) N(6)-methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2. Nature Genetics 52, 870-877.

7. Ren, F., Lin, Q., Gong, G., Du, X., Dan, H., Qin, W., Miao, R., Xiong, Y., Xiao, R., Li, X., Gui, J.*, Mei, J.* (2020). Igf2bp3 maintains maternal RNA stability and ensures early embryo development in zebra?sh. Communications Biology 3, 94.

8. Xiao, R.#*, Chen, JY#, Liang, Z#, Luo, D., Chen, G., Lu, Z., Chen, Y., Zhou, B., Li, H., Du, X., Yang, Y., San, M., Wei, X., Liu, W., Lecuyer, E., Graveley, B., Yeo, G., Burge, C., Zhang, M., Zhou, Y. and Fu, XD* (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-based Regulation of Transcription. Cell. 178(1):107-121.

9. Chen, L., Chen, JY., Zhang, X., Gu, Y., Xiao, R., Shao, C., Tang, P., Qian, H., Luo, D., Li, H., Zhou, Y., Zhang, D., and Fu, XD (2017) R-ChIP using inactive RNase H reveals dynamic Coupling of R-loops with transcriptional pausing at gene promoters. Molecular Cell. 68(4): 745-57.

10. Wei, C.#, Xiao, R.#, Chen, L.#, Cui, H.#, Zhou, Y.#, Xue, Y., Hu, J., Zhou, B., Tsutsui, T., Qiu, J., Li, H., Tang, L. and Fu, XD (2016) RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes. Molecular Cell. 62(6):875-889.

11. Wang, L.#, Zhou, Y.#, Xu, L.#, Xiao, R.#, Lu, X., Chen, L., Chong, J., He, C., Fu, XD and Wang, D. (2015) Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature. 523(7562):621-625.

12. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C., Xiao, R., Burge, C.B. and Fu, XD (2013) SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell. 153(4):855-68.

13. Xiao, R.#, Tang, P.#, Yang, B., Huang, J., Zhou, Y., Shao, C., Li, H., Sun, H., Zhang, Y. and Fu, XD (2012) Nuclear matrix factor hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation. Molecular Cell. 45(5):656-668.


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