科学研究
20200710 Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat
发布时间:2020-09-16  来源:  阅读次数:

Dong, Y., Tu, R., Liu, H., and Qing, G.*(2020). Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat. Signal Transduct Target Ther 5, 124.


Abstract

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and proliferation. As such, most human cancers differ from normal counterpart tissues by a plethora of energetic and metabolic reprogramming. Transcription factors of the MYC family are deregulated in up to 70% of all human cancers through a variety of mechanisms. Oncogenic levels of MYC regulates almost every aspect of cellular metabolism, a recently revisited hallmark of cancer development. Meanwhile, unrestrained growth in response to oncogenic MYC expression creates dependency on MYC-driven metabolic pathways, which in principle provides novel targets for development of effective cancer therapeutics. In the current review, we summarize the significant progress made toward understanding how MYC deregulation fuels metabolic rewiring in malignant transformation.


原文链接见:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351732/


地 址:湖北省武汉市武昌区东湖路115号 邮政编码:430071 电 话:027-68750205  邮 箱:mri@whu.edu.cn

CopyRight ? 2016  版权所有:美高梅正规平台网址-网投【鼠年大吉】

XML 地图 | Sitemap 地图